People with both mental illness and skin conditions are more prone to depression and suicidal ideation. A study presented at the European College of Neuropsychopharmacology Congress indicated that among patients experiencing their first episode of psychosis, those with accompanying skin problems such as rashes, itching, or photosensitivity had a significantly increased probability of developing depression and suicidal ideation in the short term. The study suggests that skin manifestations may be an early indicator of high-risk mental illness.
This study included 481 participants experiencing their first psychotic symptoms, of whom 14.5% had skin-related manifestations at the time of the investigation. All participants received four weeks of antipsychotic treatment and follow-up assessments. The results showed that approximately 25% of those with skin problems experienced suicidal thoughts or self-harm during follow-up, compared to only about 7% of those without skin problems. Furthermore, the study found that patients who initially presented with skin symptoms were more likely to experience severe depression and had poorer overall mental and physical health during follow-up.
Homologous Mechanisms of Skin and Brain
Researchers point out that skin and brain originate from the embryonic ectoderm, and may share certain developmental or inflammatory pathways, which could explain the association between skin symptoms and mental state.
However, researchers also emphasize that current findings only show a correlation and cannot establish a causal relationship. Larger sample sizes and longitudinal studies are needed to further validate the relevant mechanisms and assess whether these findings apply to other mental illness groups such as bipolar disorder (formerly known as manic-depressive disorder) and attention deficit hyperactivity disorder (ADHD). If subsequent studies validate these findings, these skin signs may serve as auxiliary indicators for risk stratification, helping to promote early identification and personalized intervention for high-risk mental illness patients.
Further Reading
